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ea0029p1838 | Thyroid cancer | ICEECE2012

Comparative examination of somatic oncogene mutation normal and pathologic thyroid tissues of Hungarian patients

Tobias B , Balla B. , Kosa J. , Horanyi J. , Takacs I. , Bolony E. , Halaszlaki C. , Nagy Z. , Speer G. , Jaray B. , Szekely E. , Istok R. , Lakatos P.

It is established that somatic oncogene mutation (BRAF, NRAS, HRAS, KRAS) and gene translocations (RET/PTC, PAX8/PPAR-gamma) are associated with the development of thyroid cancer. Somatic single nucleotide polymorphisms were analyzed by LigthCycler melting method, while translocations were identified by real-time polymerase chain reaction technique. In 22 intraoperative thyroid tissue samples (11 pathologic and 11 normal). In tumorous sample 3 BRAF, 2 NRAS and one HRAS mutatio...

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Comparative examination of somatic oncogene mutation normal and pathologic thyroid tissues of Hungarian patients

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